The Neurobiology of Depression: Diverse Approaches Towards Novel Therapies

I wrote a mini literature review for a graduate class. Below is an excerpt.

"The increasing incidence of major depressive disorder (MDD) patients who are resistant to the clinical effects of conventional treatments has created a medical need for newer approaches to the development of drugs treating comorbid depression and anxiety. Recently, animal models of MDD have shifted towards inducing depressive-like behavior through recurrent, long-term, and unpredictable stress exposure on rodents with the goal of reversing this behavior by directly targeting the hypothesized, underlying endogenous systems mediating these effects. In order to provide evidence for the translational potential of ameliorated behavioral and cognitive effects into human pharmacology, various research groups have begun looking at the different, diverse molecular, morphological, and electrophysiological effects of stress-induced depressive-like behavior in the cortex and the subsequent reversal or attenuation by novel compounds."
About Christian

Neuroscientist at UC San Diego

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